The Causes Of Narcolepsy
What in the world
could be causing such a strange disorder as Narcolepsy?
Scientists have been asking this same question and have
discovered quite a few interesting things. In fact, the
National Institute of Neurological Disorders and Stroke
(NINDS) has combined its efforts with the National
Institute of Health (NIH) to conduct research about this
and other related sleep disorders.
Different studies such as the "Safety and Effectiveness
Study of a Single Dose of JNJ-17216498 in Patients With
Narcolepsy" and "Body Weight Regulation in Patients With
Narcolepsy", many conclusions have been made. Other studies
such as the "Effectiveness Of The Drug GSK 189254 In Treating
Patients With Narcolepsy" and "Trial of Xyrem (Sodium Oxybate)
for the Treatment of Narcolepsy" have helped to conclude that,
while there are available medications to
Thanks to some of the friendly doctors on the job, we are
provided with some simple explanations about the causes of a
very complex disorder. To make things more understandable to
the average layman, it had been explained that narcolepsy is a
chronic neurological condition caused by the inability of the
brain to exercise normal and regular sleep and wake cycles.
The underlying causes of this neurological condition are too
complex for many people to understand, but there are four major
symptoms that are associated with this condition. First,
patients experience excessive daytime sleepiness or EDS.
Second, they experience cataplexy or the sudden loss of muscle
tone. Third, they experience vivid hallucinations during sleep
or upon awakening and lastly they have brief periods of total
paralysis. People with this condition do not have the luxury to
exercise a regular sleep cycle from non-rapid eye movement to
rapid eye movement. Instead, they must seek serious medical
treatment.
One of the most common questions still remains for many
people. "What causes narcolepsy?" If we are willing to stretch
our minds a bit, a more complex explanation can be given for
this strange disorder. First, there are some simple things that
can be said to trigger the symptoms of this disorder.
According to researchers, studies show that patients who
suffer from it had developed infection, immune-system
dysfunction, trauma, hormonal changes, traumatic injuries,
tumor growth due to exposure to toxins and stress prior to
their narcolepsy symptoms attack. Although these are not
considered definite causes for the disorder, they can be
readily associated with its onset.
In addition to
this, a more complicated explanation involves the fact
that a number of variant forms of genes called Allenes
affect the condition and are located in a region of
chromosome 6 known as the HLA complex of the human gene.
I told you this was going to be complicated! Anyway,
Allenes have also been discovered to be an essential
factor associated with narcolepsy. The HLA complex makes
up the majority of interrelated genes that regulate vital
roles in the immune system function. People who are
diagnosed to have this condition have been shown to have
only specific variants in certain HLA genes.
These alone, however, are not sufficient to cause the
disorder because there are clinical studies that prove the
condition to be more unpredictable by nature. Many other genes,
aside from those which make up the HLA complex may
significantly contribute to the occurrence of narcolepsy. By
considering the group of neurons in the brainstem and in the
central brain which interact with each other to control sleep,
there are large numbers of genes which are supposed to disrupt
the brain's neurotransmitters.
These neurotransmitters keep us awake when we need to be
awake and individuals who lack these transmitters are found to
develop many symptoms. Now you see how complicated it all is!
The good news is that you do not have to be a genius to see the
symptoms or to seek medical advice if you think you may be
suffering from this condition.
As part of treatment and good management of this condition,
medical practitioners strongly suggest that patients must
adhere to certain behavioral strategies such as avoidance of
alcohol, caffeine, and nicotine before bedtime. These
behaviors, accompanied by proper medication to establish a
regular sleep every night, are the best solutions known to help
combat this strange disorder known as Narcolepsy.
Over 70 Million people in the USA suffer from some kind of
Sleep Disorder! There are actually hundreds of ways to improve
your sleep but the first thing that is needed is to raise more
awareness! If you want to sleep better tonight, you can visit
this information Sleep Aid Web Site that is packed with FREE
information: http://www.Sleep-Aid-Solutions.com
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